| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARL6IP1 (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARL6IP1 |
| Gene ID: |
23204 |
| Uniprot ID: |
AR6P1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARL6IP1 (NP_055976.1). |
| Immunogen Sequence: |
MAEGDNRSTNLLAAETASLE EQLQGWGEVMLMADKVLRWE RAWFPPAIMGVVSLVFLIIY YLDPSVLSGVSCFVMFLCLA DYLVPILAPRIFGSNKWTTE |
| Tissue Specificity | Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart. |
| Function | Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1Arl-6-Interacting Protein 1Aip-1Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic ReticulumPredominantly Localized To Intracytoplasmic MembranesPreferentially Localizes At The Er Tubules And The Edge Of The Er SheetsBoth Of Which Are Characterized By A High Membrane Curvature |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 antibodyAnti-Arl-6-Interacting Protein 1 antibodyAnti-Aip-1 antibodyAnti-Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum antibodyAnti-ARL6IP1 antibodyAnti-ARL6IP antibodyAnti-ARMER antibodyAnti-KIAA0069 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ARL6IP1 knockout (KO) 293T cells, using [KO Validated] ARL6IP1 Rabbit polyclonal antibody (STJ11100871) at 1:5000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89805/358272/STJ11100871_1__58128.1713122615.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ARL6IP1 knockout (KO) 293T cells, using [KO Validated] ARL6IP1 Rabbit polyclonal antibody (STJ11100871) at 1:5000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.")
