| Function | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor. |
| Protein Name | At-Rich Interactive Domain-Containing Protein 4bArid Domain-Containing Protein 4b180 Kda Sin3-Associated PolypeptideSin3-Associated Polypeptide P180Breast Cancer-Associated Antigen Brcaa1Histone Deacetylase Complex Subunit Sap180Retinoblastoma-Binding Protein 1-Like 1 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-9679191 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic In Breast Cancer Cells |
| Alternative Antibody Names | Anti-At-Rich Interactive Domain-Containing Protein 4b antibodyAnti-Arid Domain-Containing Protein 4b antibodyAnti-180 Kda Sin3-Associated Polypeptide antibodyAnti-Sin3-Associated Polypeptide P180 antibodyAnti-Breast Cancer-Associated Antigen Brcaa1 antibodyAnti-Histone Deacetylase Complex Subunit Sap180 antibodyAnti-Retinoblastoma-Binding Protein 1-Like 1 antibodyAnti-ARID4B antibodyAnti-BRCAA1 antibodyAnti-RBBP1L1 antibodyAnti-RBP1L1 antibodyAnti-SAP180 antibody |
Information sourced from Uniprot.org
