Anti-ARHGEF4 antibody [ARHGEF-08] (STJ16103113)

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STJ16103113-0.1
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Host: Mouse
Applications: FC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-ARHGEF4 for use in FC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : ARHGEF-08
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide
Purification: Purified by protein-A affinity chromatography.
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol: ARHGEF4
Gene ID: 50649
Uniprot ID: ARHG4_HUMAN
Immunogen: Recombinant fragment of human ARHGEF4 (amino acids 143-271)
Function Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Protein Name Rho Guanine Nucleotide Exchange Factor 4
Apc-Stimulated Guanine Nucleotide Exchange Factor 1
Asef
Asef1
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Isoform 3: Cytoplasm
Cell Projection
Ruffle Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Associated With Membrane Ruffles
Alternative Antibody Names Anti-Rho Guanine Nucleotide Exchange Factor 4 antibody
Anti-Apc-Stimulated Guanine Nucleotide Exchange Factor 1 antibody
Anti-Asef antibody
Anti-Asef1 antibody
Anti-ARHGEF4 antibody
Anti-KIAA1112 antibody

Information sourced from Uniprot.org

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