| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor 25 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARHGEF25 |
| Gene ID: |
115557 |
| Uniprot ID: |
ARHGP_HUMAN |
| Specificity: |
This antibody detects endogenous levels of GEFT at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human GEFT |
| Function | May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 25Guanine Nucleotide Exchange Factor GeftRac/Cdc42/Rho Exchange Factor GeftRhoa/Rac/Cdc42 Guanine Nucleotide Exchange Factor GeftP63rhogef |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell MembraneCytoplasmMyofibrilSarcomereHighly Colocalizes With Actin Regions |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 25 antibodyAnti-Guanine Nucleotide Exchange Factor Geft antibodyAnti-Rac/Cdc42/Rho Exchange Factor Geft antibodyAnti-Rhoa/Rac/Cdc42 Guanine Nucleotide Exchange Factor Geft antibodyAnti-P63rhogef antibodyAnti-ARHGEF25 antibodyAnti-GEFT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
