| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor 15 (560-640 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARHGEF15 |
| Gene ID: |
22899 |
| Uniprot ID: |
ARHGF_HUMAN |
| Immunogen Region: |
560-640 aa |
| Specificity: |
ARHGF Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 560-640 |
| Post Translational Modifications | Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination. Ubiquitinated.UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation. |
| Function | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 15Ephexin-5E5Vsm-Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell ProjectionDendriteExpressed Exclusively In Dendrites Of The Developing Hippocampus |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 15 antibodyAnti-Ephexin-5 antibodyAnti-E5 antibodyAnti-Vsm-Rhogef antibodyAnti-ARHGEF15 antibodyAnti-KIAA0915 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
