| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor 15 (560-640 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARHGEF15 |
| Gene ID: | 22899 |
| Uniprot ID: | ARHGF_HUMAN |
| Immunogen Region: | 560-640 aa |
| Specificity: | ARHGF Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 560-640 |
| Post Translational Modifications | Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination. Ubiquitinated.UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation. |
| Function | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 15Ephexin-5E5Vsm-Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell ProjectionDendriteExpressed Exclusively In Dendrites Of The Developing Hippocampus |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 15 antibodyAnti-Ephexin-5 antibodyAnti-E5 antibodyAnti-Vsm-Rhogef antibodyAnti-ARHGEF15 antibodyAnti-KIAA0915 antibody |
Information sourced from Uniprot.org
