| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARHGAP11B (218-267) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARHGAP11B |
| Gene ID: |
89839 |
| Uniprot ID: |
RHGBB_HUMAN |
| Immunogen Region: |
218-267 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 218-267 of human ARHGAP11B (NP_001034930.1). |
| Immunogen Sequence: |
EKKGVYQTLSWKRYQPCWVL MVSVLLHHWKALKKVNMKLL VNIREREDNV |
| Function | Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development. |
| Protein Name | Inactive Rho Gtpase-Activating Protein 11bRho-Type Gtpase-Activating Protein 11b |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Inactive Rho Gtpase-Activating Protein 11b antibodyAnti-Rho-Type Gtpase-Activating Protein 11b antibodyAnti-ARHGAP11B antibodyAnti-FAM7B1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
