| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ARHGAP10 |
| Gene ID: |
79658 |
| Uniprot ID: |
RHG10_HUMAN |
| Immunogen Region: |
470-570 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 470-570 of human ARHGAP10 (NP_078881.3). |
| Immunogen Sequence: |
LMTYELHGDFIVPAKSGSPE SRVNAIHFLVHKLPEKNKEM LDILVKHLTNVSNHSKQNLM TVANLGVVFGPTLMRPQEET VAALMDLKFQNIVVEILIEN H |
| Tissue Specificity | High levels of expression in heart and skeletal muscle. |
| Post Translational Modifications | Phosphorylated. Phosphorylated in vitro by constitutive active PKN3. |
| Function | GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. |
| Protein Name | Rho Gtpase-Activating Protein 10Gtpase Regulator Associated With Focal Adhesion Kinase 2Graf2Graf-Related Protein 2Rho-Type Gtpase-Activating Protein 10 |
| Database Links | Reactome: R-HSA-211728Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneEndosome MembraneAssociation To Cell Membrane Is Dependent On Ph DomainColocalized With Mical1Rab8aRab8b And Rab10 On Endosomal Tubules |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 10 antibodyAnti-Gtpase Regulator Associated With Focal Adhesion Kinase 2 antibodyAnti-Graf2 antibodyAnti-Graf-Related Protein 2 antibodyAnti-Rho-Type Gtpase-Activating Protein 10 antibodyAnti-ARHGAP10 antibodyAnti-GRAF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
