| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AQP9 |
| Gene ID: | 366 |
| Uniprot ID: | AQP9_HUMAN |
| Immunogen Region: | 211-295 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 211-295 of human AQP9 (NP_066190.2). |
| Immunogen Sequence: | SGCAMNPARDLSPRLFTALA GWGFEVFRAGNNFWWIPVVG PLVGAVIGGLIYVLVIEIHH PEPDSVFKTEQSEDKPEKYE LSVIM |
| Tissue Specificity | Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis. It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium. |
| Protein Name | Aquaporin-9 Aqp-9 Aquaglyceroporin-9 Small Solute Channel 1 |
| Database Links | Reactome: R-HSA-432030 Reactome: R-HSA-432047 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Functions At The Hepatocyte Basolateral Membrane |
| Alternative Antibody Names | Anti-Aquaporin-9 antibody Anti-Aqp-9 antibody Anti-Aquaglyceroporin-9 antibody Anti-Small Solute Channel 1 antibody Anti-AQP9 antibody Anti-SSC1 antibody |
Information sourced from Uniprot.org