Anti-AQP9 antibody (211-295) (STJ111279)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AQP9 (211-295) antibody for use in WB, IHC-P, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AQP9 |
| Gene ID | 366 |
| Uniprot ID | AQP9_HUMAN |
| Immunogen Region | 211-295 |
| Immunogen Sequence | SGCAMNPARDLSPRLFTALA GWGFEVFRAGNNFWWIPVVG PLVGAVIGGLIYVLVIEIHH PEPDSVFKTEQSEDKPEKYE LSVIM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 211-295 of human AQP9 (NP_066190.2). |
Additional Info
| Tissue Specificity | Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis. It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium. |
| Protein Name | Aquaporin-9Aqp-9Aquaglyceroporin-9Small Solute Channel 1 |
| Database Links | Reactome: R-HSA-432030Reactome: R-HSA-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneFunctions At The Hepatocyte Basolateral Membrane |
| Alternative Antibody Names | Anti-Aquaporin-9 antibodyAnti-Aqp-9 antibodyAnti-Aquaglyceroporin-9 antibodyAnti-Small Solute Channel 1 antibodyAnti-AQP9 antibodyAnti-SSC1 antibody |
Information sourced from Uniprot.org