| Tissue Specificity | Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. |
| Function | DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3aA3aPhorbolin-1 |
| Database Links | Reactome: R-HSA-72200Reactome: R-HSA-75094 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3a antibodyAnti-A3a antibodyAnti-Phorbolin-1 antibodyAnti-APOBEC3A antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and TAGLN2 knockout (KO) 293T cells, using [KO Validated] TAGLN2 Rabbit pAb (STJ28844) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/102094/411412/STJ28844_1__68510.1744897937.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TAGLN2 knockout (KO) 293T cells, using [KO Validated] TAGLN2 Rabbit pAb (STJ28844) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 5s.")
