| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Amyloid beta precursor like protein 1 precursor-like protein 1 (360-440 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | APLP1 |
| Gene ID: | 333 |
| Uniprot ID: | APLP1_HUMAN |
| Immunogen Region: | 360-440 aa |
| Specificity: | APLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein. |
| Immunogen: | Synthesized peptide derived from APLP-1 at the amino acid range 360-440 |
| Post Translational Modifications | Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. |
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| Protein Name | Amyloid Beta Precursor Like Protein 1 Amyloid Beta A4 Precursor-Like Protein 1 Amyloid-Like Protein 1 Aplp Aplp-1 Cleaved Into - C30 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein C30: Cytoplasm C-Terminally Processed In The Golgi Complex |
| Alternative Antibody Names | Anti-Amyloid Beta Precursor Like Protein 1 antibody Anti-Amyloid Beta antibody Anti-A4 Precursor-Like Protein 1 antibody Anti-Amyloid-Like Protein 1 antibody Anti-Aplp antibody Anti-Aplp-1 Cleaved Into - C30 antibody Anti-APLP1 antibody |
Information sourced from Uniprot.org