• Immunohistochemical analysis of paraffin-embedded mouse-ovary, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded mouse-ovary, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded mouse-ovary, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded mouse-ovary, antibody was diluted at 1:100
  • Western blot analysis of extracts from K562 cells, using APLP-1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-APLP1 antibody (360-440 aa) (STJ96423)

SKU:
STJ96423

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Amyloid beta precursor like protein 1 precursor-like protein 1 (360-440 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: APLP1
Gene ID: 333
Uniprot ID: APLP1_HUMAN
Immunogen Region: 360-440 aa
Specificity: APLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein.
Immunogen: Synthesized peptide derived from APLP-1 at the amino acid range 360-440
Post Translational Modifications Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
Function May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Protein Name Amyloid Beta Precursor Like Protein 1
Amyloid Beta
A4 Precursor-Like Protein 1
Amyloid-Like Protein 1
Aplp
Aplp-1 Cleaved Into - C30
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
C30: Cytoplasm
C-Terminally Processed In The Golgi Complex
Alternative Antibody Names Anti-Amyloid Beta Precursor Like Protein 1 antibody
Anti-Amyloid Beta antibody
Anti-A4 Precursor-Like Protein 1 antibody
Anti-Amyloid-Like Protein 1 antibody
Anti-Aplp antibody
Anti-Aplp-1 Cleaved Into - C30 antibody
Anti-APLP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance