Anti-APLNR antibody (141-190 aa) (STJ91630)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human AGTRL1 at the amino acid range 141-190
General Information
| Short Description | Rabbit polyclonal anti-Apelin receptor (141-190 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APLNR |
| Gene ID | 187 |
| Uniprot ID | APJ_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human AGTRL1 at the amino acid range 141-190 |
| Immunogen Region | 141-190 aa |
| Specificity | APLNR Polyclonal Antibody detects endogenous levels of APLNR protein. |
Additional Info
| Function | G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.may be involved in the development of AIDS dementia. |
| Protein Name | Apelin ReceptorAngiotensin Receptor-Like 1G-Protein Coupled Receptor ApjG-Protein Coupled Receptor Hg11 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneAfter Exposure To Apelin (Apln)Internalized From The Cell Surface Into An Endosomal Recycling CompartmentFrom Where It Is Recycled To The Cell MembraneAfter Exposure To Apelin Receptor Early Endogenous Ligand (Apela) |
| Alternative Antibody Names | Anti-Apelin Receptor antibodyAnti-Angiotensin Receptor-Like 1 antibodyAnti-G-Protein Coupled Receptor Apj antibodyAnti-G-Protein Coupled Receptor Hg11 antibodyAnti-APLNR antibodyAnti-AGTRL1 antibodyAnti-APJ antibody |
Information sourced from Uniprot.org