| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | APIP |
| Gene ID: | 51074 |
| Uniprot ID: | MTNB_HUMAN |
| Immunogen Region: | 1-242 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2). |
| Immunogen Sequence: | MSGCDAREGDCCSRRCGAQD KEHPRYLIPELCKQFYHLGW VTGTGGGISLKHGDEIYIAP SGVQKERIQPEDMFVCDINE KDISGPSPSKKLKKSQCTPL FMNAYTMRGAGAVIHTHSKA AVMATLLFPGREFKITHQEM IKGIKKCTSGGYYRYDDMLV VPIIENTPEEKDLKDRMAHA MNEYPDSCAVLVRRHGVYVW GETWEKAKTMCECYDYLFDI AVSMKKVGLDPSQLPVGEN |
| Tissue Specificity | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. |
| Function | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. |
| Protein Name | Methylthioribulose-1-Phosphate DehydrataseMtru-1-P DehydrataseApaf1-Interacting ProteinHapip |
| Database Links | Reactome: R-HSA-111458Reactome: R-HSA-1237112Reactome: R-HSA-9627069 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Methylthioribulose-1-Phosphate Dehydratase antibodyAnti-Mtru-1-P Dehydratase antibodyAnti-Apaf1-Interacting Protein antibodyAnti-Hapip antibodyAnti-APIP antibodyAnti-CGI-29 antibody |
Information sourced from Uniprot.org