| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AP3B1 (895-1094) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AP3B1 |
| Gene ID: |
8546 |
| Uniprot ID: |
AP3B1_HUMAN |
| Immunogen Region: |
895-1094 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 895-1094 of human AP3B1 (NP_003655.3). |
| Immunogen Sequence: |
FGDKMVSIQITLNNTTDRKI ENIHIGEKKLPIGMKMHVFN PIDSLEPEGSITVSMGIDFC DSTQTASFQLCTKDDCFNVN IQPPVGELLLPVAMSEKDFK KEQGVLTGMNETSAVIIAAP QNFTPSVIFQKVVNVANVGA VPSGQDNIHRFAAKTVHSGS LMLVTVELKEGSTAQLIINT EKTVIGSVLLRELKPVLSQG |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated on serine residues. Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) impairs interaction with KIF3A. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue. |
| Function | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Protein Name | Ap-3 Complex Subunit Beta-1Adaptor Protein Complex Ap-3 Subunit Beta-1Adaptor-Related Protein Complex 3 Subunit Beta-1Beta-3a-AdaptinClathrin Assembly Protein Complex 3 Beta-1 Large Chain |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6802952 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusComponent Of The Coat Surrounding The Cytoplasmic Face Of Coated Vesicles Located At The Golgi Complex |
| Alternative Antibody Names | Anti-Ap-3 Complex Subunit Beta-1 antibodyAnti-Adaptor Protein Complex Ap-3 Subunit Beta-1 antibodyAnti-Adaptor-Related Protein Complex 3 Subunit Beta-1 antibodyAnti-Beta-3a-Adaptin antibodyAnti-Clathrin Assembly Protein Complex 3 Beta-1 Large Chain antibodyAnti-AP3B1 antibodyAnti-ADTB3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
