Anti-AOC1 antibody (20-300) (STJ28005)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AOC1 (20-300) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AOC1 |
| Gene ID | 26 |
| Uniprot ID | AOC1_HUMAN |
| Immunogen Region | 20-300 |
| Immunogen Sequence | EPSPGTLPRKAGVFSDLSNQ ELKAVHSFLWSKKELRLQPS STTTMAKNTVFLIEMLLPKK YHVLRFLDKGERHPVREARA VIFFGDQEHPNVTEFAVGPL PGPCYMRALSPRPGYQSSWA SRPISTAEYALLYHTLQEAT KPLHQFFLNTTGFSFQDCHD RCLAFTDVAPRGVASGQRRS WLIIQRYVEGYFLHPTGLEL LVDHGSTDAGHWAVEQVWYN GKFYGSPEELARKYADGEV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2). |
Additional Info
| Tissue Specificity | Widely expressed with higher expression in placenta and kidney. |
| Post Translational Modifications | N-glycosylated. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. |
| Function | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes. |
| Protein Name | Diamine Oxidase Copper-ContainingDiamine OxidaseAmiloride-Binding ProteinAmiloride-Binding Protein 1Amine Oxidase Copper Domain-Containing Protein 1HistaminaseKidney Amine OxidaseKaoKdao |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular Side |
| Alternative Antibody Names | Anti-Diamine Oxidase Copper-Containing antibodyAnti-Diamine Oxidase antibodyAnti-Amiloride-Binding Protein antibodyAnti-Amiloride-Binding Protein 1 antibodyAnti-Amine Oxidase Copper Domain-Containing Protein 1 antibodyAnti-Histaminase antibodyAnti-Kidney Amine Oxidase antibodyAnti-Kao antibodyAnti-Kdao antibodyAnti-AOC1 antibodyAnti-ABP antibodyAnti-ABP1 antibodyAnti-DAO antibody |
Information sourced from Uniprot.org