| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AOC1 |
| Gene ID: |
26 |
| Uniprot ID: |
AOC1_HUMAN |
| Immunogen Region: |
20-300 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2). |
| Immunogen Sequence: |
EPSPGTLPRKAGVFSDLSNQ ELKAVHSFLWSKKELRLQPS STTTMAKNTVFLIEMLLPKK YHVLRFLDKGERHPVREARA VIFFGDQEHPNVTEFAVGPL PGPCYMRALSPRPGYQSSWA SRPISTAEYALLYHTLQEAT KPLHQFFLNTTGFSFQDCHD RCLAFTDVAPRGVASGQRRS WLIIQRYVEGYFLHPTGLEL LVDHGSTDAGHWAVEQVWYN GKFYGSPEELARKYADGEV |
| Tissue Specificity | Widely expressed with higher expression in placenta and kidney. |
| Post Translational Modifications | N-glycosylated. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. |
| Function | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes. |
| Protein Name | Diamine Oxidase Copper-ContainingDiamine OxidaseAmiloride-Binding ProteinAmiloride-Binding Protein 1Amine Oxidase Copper Domain-Containing Protein 1HistaminaseKidney Amine OxidaseKaoKdao |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular Side |
| Alternative Antibody Names | Anti-Diamine Oxidase Copper-Containing antibodyAnti-Diamine Oxidase antibodyAnti-Amiloride-Binding Protein antibodyAnti-Amiloride-Binding Protein 1 antibodyAnti-Amine Oxidase Copper Domain-Containing Protein 1 antibodyAnti-Histaminase antibodyAnti-Kidney Amine Oxidase antibodyAnti-Kao antibodyAnti-Kdao antibodyAnti-AOC1 antibodyAnti-ABP antibodyAnti-ABP1 antibodyAnti-DAO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
