| Short Description : | Rabbit polyclonal ANXA13 (1-316) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANXA13 |
| Gene ID: | 312 |
| Uniprot ID: | ANX13_HUMAN |
| Immunogen Region: | 1-316 |
| Immunogen Sequence: | MGNRHAKASSPQGFDVDRDA KKLNKACKGMGTNEAAIIEI LSGRTSDERQQIKQKYKATY GKELEEVLKSELSGNFEKTA LALLDRPSEYAARQLQKAMK GLGTDESVLIEVLCTRTNKE IIAIKEAYQRLFDRSLESDV KGDTSGNLKKILVSLLQANR NEGDDVDKDLAGQDAKDLYD AGEGRWGTDELAFNEVLAKR SYKQLRATFQAYQILIGKDI EEAIEEETSGDLQKAYLTL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human ANXA13 (NP_004297.2). |
| Tissue Specificity | Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum. |
| Function | Isoform A: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. Isoform B: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium. |
| Protein Name | Annexin A13Annexin XiiiAnnexin-13Intestine-Specific AnnexinIsa |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneCell MembraneLipid-AnchorCytoplasmic VesicleMyristoylation Anchors The Protein To The MembraneBut The Protein Also Displays Calcium-DependentReversible Binding To Lipid MembranesAssociated With The Plasma Membrane Of UndifferentiatedProliferating Crypt Epithelial Cells As Well As Differentiated Villus Enterocytes |
| Alternative Antibody Names | Anti-Annexin A13 antibodyAnti-Annexin Xiii antibodyAnti-Annexin-13 antibodyAnti-Intestine-Specific Annexin antibodyAnti-Isa antibodyAnti-ANXA13 antibodyAnti-ANX13 antibody |
Information sourced from Uniprot.org
