| Function | May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events.in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes.the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth.the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface.the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites. Involved in GLUT1 endosome-to-plasma membrane trafficking.the function is dependent of association with VPS29. Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. |
| Protein Name | Ankyrin Repeat Domain-Containing Protein 27Vps9 Domain-Containing Protein |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Early EndosomeLate EndosomeCytoplasmic Vesicle MembraneLysosomeCell MembraneMelanosomeColocalizes With Vamp7 In Transport Vesicles In The Shaft Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Ankyrin Repeat Domain-Containing Protein 27 antibodyAnti-Vps9 Domain-Containing Protein antibodyAnti-ANKRD27 antibodyAnti-PP12899 antibody |
Information sourced from Uniprot.org
