| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rabankyrin-5 (922-972 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANKFY1 |
| Gene ID: |
51479 |
| Uniprot ID: |
ANFY1_HUMAN |
| Immunogen Region: |
922-972 aa |
| Specificity: |
This antibody detects endogenous levels of human ANFY1 |
| Immunogen: |
Synthesized peptide derived from the human ANFY1 at the amino acid range 922-972 |
| Function | Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis.the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. |
| Protein Name | Rabankyrin-5Rank-5Ankyrin Repeat And Fyve Domain-Containing Protein 1Ankyrin Repeats Hooked To A Zinc Finger Motif |
| Database Links | Reactome: R-HSA-9013405 |
| Cellular Localisation | CytoplasmEndosome MembranePeripheral Membrane ProteinEarly EndosomeAlso Associated With Endosomal MembranesLocalizes To Macropinosomes |
| Alternative Antibody Names | Anti-Rabankyrin-5 antibodyAnti-Rank-5 antibodyAnti-Ankyrin Repeat And Fyve Domain-Containing Protein 1 antibodyAnti-Ankyrin Repeats Hooked To A Zinc Finger Motif antibodyAnti-ANKFY1 antibodyAnti-ANKHZN antibodyAnti-KIAA1255 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
