| Function | Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis.the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. |
| Protein Name | Rabankyrin-5Rank-5Ankyrin Repeat And Fyve Domain-Containing Protein 1Ankyrin Repeats Hooked To A Zinc Finger Motif |
| Database Links | Reactome: R-HSA-9013405 |
| Cellular Localisation | CytoplasmEndosome MembranePeripheral Membrane ProteinEarly EndosomeAlso Associated With Endosomal MembranesLocalizes To Macropinosomes |
| Alternative Antibody Names | Anti-Rabankyrin-5 antibodyAnti-Rank-5 antibodyAnti-Ankyrin Repeat And Fyve Domain-Containing Protein 1 antibodyAnti-Ankyrin Repeats Hooked To A Zinc Finger Motif antibodyAnti-ANKFY1 antibodyAnti-ANKHZN antibodyAnti-KIAA1255 antibody |
Information sourced from Uniprot.org
