| Host: |
Rabbit |
| Applications: |
IF/ICC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANK3 |
| Gene ID: |
288 |
| Uniprot ID: |
ANK3_HUMAN |
| Immunogen Region: |
833-977 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 833-977 of human ANK3 (NP_066267.2). |
| Immunogen Sequence: |
KMNVPETMNEVLDMSDDEVR KANAPEMLSDGEYISDVEEG EDAMTGDTDKYLGPQDLKEL GDDSLPAEGYMGFSLGARSA SLRSFSSDRSYTLNRSSYAR DSMMIEELLVPSKEQHLTFT REFDSDSLRHYSWAADTLDN VNLVS |
| Tissue Specificity | Expressed in brain, neurons, muscles and other tissues. |
| Function | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. |
| Protein Name | Ankyrin-3Ank-3Ankyrin-G |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-6807878 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonCell MembraneSarcolemmaPostsynaptic Cell MembraneLysosomeT-TubuleIn Skeletal MuscleLocalized At Costameres And Neuromuscular JunctionsIn MacrophagesAssociated With LysosomesIsoform 5: CytoplasmGolgi Apparatus |
| Alternative Antibody Names | Anti-Ankyrin-3 antibodyAnti-Ank-3 antibodyAnti-Ankyrin-G antibodyAnti-ANK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
