| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ankyrin-2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANK2 |
| Gene ID: |
287 |
| Uniprot ID: |
ANK2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Ankyrin B at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from the human Ankyrin B |
| Post Translational Modifications | Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function. |
| Function | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate. In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration. |
| Protein Name | Ankyrin-2Ank-2Ankyrin-BBrain AnkyrinNon-Erythroid Ankyrin |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-6807878 |
| Cellular Localisation | CytoplasmCytoskeletonMembraneMyofibrilSarcomereM LineApical Cell MembraneCell MembranePostsynaptic Cell MembraneEarly EndosomeRecycling EndosomeLysosomeMitochondrionZ LineSarcolemmaT-TubuleExpressed At The Apical Membrane Of Airway Lung Epithelial CellsLocalized To The Plasma Membrane Of The Inner Segments Of Photoreceptors In RetinaColocalizes With Sptbn1 In A Distinct Intracellular Compartment Of Neonatal CardiomyocytesIn Skeletal MuscleLocalizes To Neuromuscular JunctionsLocalizes With Puncta At Mitochondria EndsColocalizes And Cotransports On Motile Vesicles With Rabgap1l |
| Alternative Antibody Names | Anti-Ankyrin-2 antibodyAnti-Ank-2 antibodyAnti-Ankyrin-B antibodyAnti-Brain Ankyrin antibodyAnti-Non-Erythroid Ankyrin antibodyAnti-ANK2 antibodyAnti-ANKB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
