| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANAPC10 |
| Gene ID: | 10393 |
| Uniprot ID: | APC10_HUMAN |
| Immunogen Region: | 1-185 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human ANAPC10 (NP_055700.2). |
| Immunogen Sequence: | MTTPNKTPPGADPKQLERTG TVREIGSQAVWSLSSCKPGF GVDQLRDDNLETYWQSDGSQ PHLVNIQFRRKTTVKTLCIY ADYKSDESYTPSKISVRVGN NFHNLQEIRQLELVEPSGWI HVPLTDNHKKPTRTFMIQIA VLANHQNGRDTHMRQIKIYT PVEESSIGKFPRCTTIDFMM YRSIR |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. |
| Protein Name | Anaphase-Promoting Complex Subunit 10 Apc10 Cyclosome Subunit 10 |
| Database Links | Reactome: R-HSA-141430 Reactome: R-HSA-174048 Reactome: R-HSA-174084 Reactome: R-HSA-174154 Reactome: R-HSA-174178 Reactome: R-HSA-174184 Reactome: R-HSA-176407 Reactome: R-HSA-176408 Reactome: R-HSA-176409 Reactome: R-HSA-176412 Reactome: R-HSA-179409 Reactome: R-HSA-2467813 Reactome: R-HSA-2559582 Reactome: R-HSA-68867 Reactome: R-HSA-69017 Reactome: R-HSA-8853884 Reactome: R-HSA-9687136 Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 10 antibody Anti-Apc10 antibody Anti-Cyclosome Subunit 10 antibody Anti-ANAPC10 antibody Anti-APC10 antibody |
Information sourced from Uniprot.org