| Short Description : | Rabbit polyclonal AMOTL1 (810-900) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AMOTL1 |
| Gene ID: | 154810 |
| Uniprot ID: | AMOL1_HUMAN |
| Immunogen Region: | 810-900 |
| Immunogen Sequence: | LTSSQLAEEKKEEKTWKGSI GLLLGKEHHEHASAPLLPPP PTSALSSIASTTAASSAHAK TGSKDSSTQTDKSAELFWPS MASLPSRGRLS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 810-900 of human AMOTL1 (NP_570899.1). |
| Post Translational Modifications | Polyubiquitinated by NEDD4, leading to proteasomal degradation. |
| Function | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. |
| Protein Name | Angiomotin-Like Protein 1 |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | Cell JunctionTight Junction |
| Alternative Antibody Names | Anti-Angiomotin-Like Protein 1 antibodyAnti-AMOTL1 antibody |
Information sourced from Uniprot.org
