| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AMD1 (75-334) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AMD1 |
| Gene ID: |
262 |
| Uniprot ID: |
DCAM_HUMAN |
| Immunogen Region: |
75-334 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 75-334 of human AMD1 (NP_001625.2). |
| Immunogen Sequence: |
RRFILKTCGTTLLLKALVPL LKLARDYSGFDSIQSFFYSR KNFMKPSHQGYPHRNFQEEI EFLNAIFPNGAAYCMGRMNS DCWYLYTLDFPESRVISQPD QTLEILMSELDPAVMDQFYM KDGVTAKDVTRESGIRDLIP GSVIDATMFNPCGYSMNGMK SDGTYWTIHITPEPEFSYVS FETNLSQTSYDDLIRKVVEV FKPGKFVTTLFVNQSSKCRT VLASPQKIEGFKRLDCQSA |
| Post Translational Modifications | Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. |
| Function | Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. |
| Protein Name | S-Adenosylmethionine Decarboxylase ProenzymeAdometdcSamdc Cleaved Into - S-Adenosylmethionine Decarboxylase Alpha Chain - S-Adenosylmethionine Decarboxylase Beta Chain |
| Database Links | Reactome: R-HSA-351202 |
| Alternative Antibody Names | Anti-S-Adenosylmethionine Decarboxylase Proenzyme antibodyAnti-Adometdc antibodyAnti-Samdc Cleaved Into - S-Adenosylmethionine Decarboxylase Alpha Chain - S-Adenosylmethionine Decarboxylase Beta Chain antibodyAnti-AMD1 antibodyAnti-AMD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
