| Tissue Specificity | Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. |
| Function | May function as protein hydroxylase.can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - MitochondrialAlkylated Dna Repair Protein Alkb Homolog 7Spermatogenesis Cell Proliferation-Related ProteinSpermatogenesis-Associated Protein 11 |
| Database Links | |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - Mitochondrial antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 7 antibodyAnti-Spermatogenesis Cell Proliferation-Related Protein antibodyAnti-Spermatogenesis-Associated Protein 11 antibodyAnti-ALKBH7 antibodyAnti-ABH7 antibodyAnti-SPATA11 antibodyAnti-UNQ6002 antibodyAnti-PRO34564 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HepG2 cells using [KD Validated] RAB27A Rabbit polyclonal antibody (STJ25258) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/100398/386820/STJ25258_1__87091.1713155968.jpg?c=1 "Immunofluorescence analysis of HepG2 cells using [KD Validated] RAB27A Rabbit polyclonal antibody (STJ25258) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
