Anti-ALKBH7 antibody (1-221) (STJ22590)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ALKBH7 (1-221) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALKBH7 |
| Gene ID | 84266 |
| Uniprot ID | ALKB7_HUMAN |
| Immunogen Region | 1-221 |
| Immunogen Sequence | MAGTGLLALRTLPGPSWVRG SGPSVLSRLQDAAVVRPGFL STAEEETLSRELEPELRRRR YEYDHWDAAIHGFRETEKSR WSEASRAILQRVQAAAFGPG QTLLSSVHVLDLEARGYIKP HVDSIKFCGATIAGLSLLSP SVMRLVHTQEPGEWLELLLE PGSLYILRGSARYDFSHEIL RDEESFFGERRIPRGRRISV ICRSLPEGMGPGESGQPPPA C |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1). |
Additional Info
| Tissue Specificity | Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. |
| Function | May function as protein hydroxylase.can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - MitochondrialAlkylated Dna Repair Protein Alkb Homolog 7Spermatogenesis Cell Proliferation-Related ProteinSpermatogenesis-Associated Protein 11 |
| Database Links | |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - Mitochondrial antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 7 antibodyAnti-Spermatogenesis Cell Proliferation-Related Protein antibodyAnti-Spermatogenesis-Associated Protein 11 antibodyAnti-ALKBH7 antibodyAnti-ABH7 antibodyAnti-SPATA11 antibodyAnti-UNQ6002 antibodyAnti-PRO34564 antibody |
Information sourced from Uniprot.org