Anti-ALKBH4 antibody [R04-4B4] (STJA0034003)

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STJA0034003
£133.50 - £281.50
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Host: Rabbit
Applications: WB/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-ALKBH4 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R04-4B4
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/mL
Dilution Range: WB 1:500-1:1000
IP 1:20
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: ALKBH4
Gene ID: 54784
Uniprot ID: ALKB4_HUMAN
Immunogen: Recombinant protein of human ALKBH4
Tissue Specificity Widely expressed, with highest expression in pancreas, ovary and spleen.
Function Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Protein Name Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
Alkylated Dna Repair Protein Alkb Homolog 4
Dna N6-Methyl Adenine Demethylase Alkbh4
Lysine-Specific Demethylase Alkbh4
Database Links
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Midbody
Associates With The Contractile Ring And Midbody
Alternative Antibody Names Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 antibody
Anti-Alkylated Dna Repair Protein Alkb Homolog 4 antibody
Anti-Dna N6-Methyl Adenine Demethylase Alkbh4 antibody
Anti-Lysine-Specific Demethylase Alkbh4 antibody
Anti-ALKBH4 antibody
Anti-ABH4 antibody

Information sourced from Uniprot.org

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