| Function | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. |
| Protein Name | Chitobiosyldiphosphodolichol Beta-MannosyltransferaseAsparagine-Linked Glycosylation Protein 1 HomologBeta-1 -4-MannosyltransferaseGdp-Man -Glcnac2-Pp-Dolichol MannosyltransferaseGdp-Mannose-Dolichol Diphosphochitobiose MannosyltransferaseMannosyltransferase-1Mt-1Hmat-1 |
| Database Links | Reactome: R-HSA-446193Reactome: R-HSA-4549380 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Chitobiosyldiphosphodolichol Beta-Mannosyltransferase antibodyAnti-Asparagine-Linked Glycosylation Protein 1 Homolog antibodyAnti-Beta-1 -4-Mannosyltransferase antibodyAnti-Gdp-Man -Glcnac2-Pp-Dolichol Mannosyltransferase antibodyAnti-Gdp-Mannose-Dolichol Diphosphochitobiose Mannosyltransferase antibodyAnti-Mannosyltransferase-1 antibodyAnti-Mt-1 antibodyAnti-Hmat-1 antibodyAnti-ALG1 antibodyAnti-HMAT1 antibodyAnti-HMT1 antibodyAnti-PSEC0061 antibodyAnti-UNQ861 antibodyAnti-PRO1870 antibody |
Information sourced from Uniprot.org
