| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ALDH3B1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 55kDa band observed in Human Peripheral Blood Mononucleocytes and in lysates of cell line K562 (calculated MW of 51.8kDa according to NP_000685.1). Recommended concentration: 0. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ALDH3B1 |
| Gene ID: |
221 |
| Uniprot ID: |
AL3B1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_000685.1 |
| Specificity: |
This antibody is expected to recognize isoform a (NP_000685.1) only. This antibody is not expected to cross react with ALDH3B2. Reported variants represent identical protein: NP_000685.1, NP_001154945.1 |
| Immunogen Sequence: |
QDLHKSAFESEVSE |
| Post Translational Modifications | Dually lipidated in the C-terminus.prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. |
| Function | Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form. |
| Protein Name | Aldehyde Dehydrogenase Family 3 Member B1 Aldehyde Dehydrogenase 7Long-Chain Fatty Aldehyde DehydrogenaseMedium-Chain Fatty Aldehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9845614 |
| Cellular Localisation | Cell MembraneLipid-AnchorPrimarily In The Plasma Membrane As Well As In Some Punctate Structures In The Cytoplasm |
| Alternative Antibody Names | Anti-Aldehyde Dehydrogenase Family 3 Member B1 antibodyAnti-Aldehyde Dehydrogenase 7 antibodyAnti-Long-Chain Fatty Aldehyde Dehydrogenase antibodyAnti-Medium-Chain Fatty Aldehyde Dehydrogenase antibodyAnti-ALDH3B1 antibodyAnti-ALDH7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
