| Function | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. |
| Protein Name | Aflatoxin B1 Aldehyde Reductase Member 2Afb1 Aldehyde Reductase 1Afb1-Ar 1Aldoketoreductase 7Succinic Semialdehyde ReductaseSsa Reductase |
| Database Links | Reactome: R-HSA-5423646 |
| Cellular Localisation | MitochondrionGolgi ApparatusCytoplasm |
| Alternative Antibody Names | Anti-Aflatoxin B1 Aldehyde Reductase Member 2 antibodyAnti-Afb1 Aldehyde Reductase 1 antibodyAnti-Afb1-Ar 1 antibodyAnti-Aldoketoreductase 7 antibodyAnti-Succinic Semialdehyde Reductase antibodyAnti-Ssa Reductase antibodyAnti-AKR7A2 antibodyAnti-AFAR antibodyAnti-AFAR1 antibodyAnti-AKR7 antibody |
Information sourced from Uniprot.org
