| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Aflatoxin B1 aldehyde reductase member 2 (219-269) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKR7A2 |
| Gene ID: | 8574 |
| Uniprot ID: | ARK72_HUMAN |
| Immunogen Region: | 219-269 |
| Specificity: | This antibody detects endogenous levels of human ARK72 |
| Immunogen: | Synthesized peptide derived from human ARK72 AA range: 219-269 |
| Function | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. |
| Protein Name | Aflatoxin B1 Aldehyde Reductase Member 2 Afb1 Aldehyde Reductase 1 Afb1-Ar 1 Aldoketoreductase 7 Succinic Semialdehyde Reductase Ssa Reductase |
| Database Links | Reactome: R-HSA-5423646 |
| Cellular Localisation | Mitochondrion Golgi Apparatus Cytoplasm |
| Alternative Antibody Names | Anti-Aflatoxin B1 Aldehyde Reductase Member 2 antibody Anti-Afb1 Aldehyde Reductase 1 antibody Anti-Afb1-Ar 1 antibody Anti-Aldoketoreductase 7 antibody Anti-Succinic Semialdehyde Reductase antibody Anti-Ssa Reductase antibody Anti-AKR7A2 antibody Anti-AFAR antibody Anti-AFAR1 antibody Anti-AKR7 antibody |
Information sourced from Uniprot.org