| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Human/Mouse/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-AIF1/Iba1 (Full Length) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: | Antigen affinity purified serum |
| Dilution Range: | WB 1:1000 ICC 1:500-1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AIF1 |
| Gene ID: | 199 |
| Uniprot ID: | AIF1_HUMAN |
| Immunogen Region: | Full Length |
| Immunogen: | Full-length human AIF1 expressed in and purified from E. coli |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Protein Name | Allograft Inflammatory Factor 1 Aif-1 Ionized Calcium-Binding Adapter Molecule 1 Protein G1 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Phagocytic Cup Associated With The Actin Cytoskeleton At Membrane Ruffles And At Sites Of Phagocytosis |
| Alternative Antibody Names | Anti-Allograft Inflammatory Factor 1 antibody Anti-Aif-1 antibody Anti-Ionized Calcium-Binding Adapter Molecule 1 antibody Anti-Protein G1 antibody Anti-AIF1 antibody Anti-G1 antibody Anti-IBA1 antibody |
Information sourced from Uniprot.org