| Function | Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. |
| Protein Name | Alanine--Glyoxylate Aminotransferase 2 - MitochondrialAgt 2(R-3-Amino-2-Methylpropionate--Pyruvate TransaminaseBeta-Alaat IiBeta-Alanine-Pyruvate AminotransferaseD-3-Aminoisobutyrate-Pyruvate AminotransferaseD-AibatD-Beta-Aminoisobutyrate-Pyruvate Aminotransferase |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-73621 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Alanine--Glyoxylate Aminotransferase 2 - Mitochondrial antibodyAnti-Agt 2 antibodyAnti-(R-3-Amino-2-Methylpropionate--Pyruvate Transaminase antibodyAnti-Beta-Alaat Ii antibodyAnti-Beta-Alanine-Pyruvate Aminotransferase antibodyAnti-D-3-Aminoisobutyrate-Pyruvate Aminotransferase antibodyAnti-D-Aibat antibodyAnti-D-Beta-Aminoisobutyrate-Pyruvate Aminotransferase antibodyAnti-AGXT2 antibodyAnti-AGT2 antibody |
Information sourced from Uniprot.org
