| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | AEN |
| Gene ID: | 64782 |
| Uniprot ID: | AEN_HUMAN |
| Immunogen Region: | 1-325 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AEN (NP_073604.3). |
| Immunogen Sequence: | MVPREAPESAQCLCPSLTIP NAKDVLRKRHKRRSRQHQRF MARKALLQEQGLLSMPPEPG SSPLPTPFGAATATEAASSG KQCLRAGSGSAPCSRRPAPG KASGPLPSKCVAIDCEMVGT GPRGRVSELARCSIVSYHGN VLYDKYIRPEMPIADYRTRW SGITRQHMRKAVPFQVAQKE ILKLLKGKVVVGHALHNDFQ ALKYVHPRSQTRDTTYVPNF LSEPGLHTRARVSLKDLAL |
| Function | Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. |
| Protein Name | Apoptosis-Enhancing NucleaseInterferon-Stimulated 20 Kda Exonuclease-Like 1 |
| Cellular Localisation | NucleusNucleolusLocalized Predomintly In The NucleolusTranslocates From The Nucleolus To The Nucleoplasm Upon Apoptosis Induction |
| Alternative Antibody Names | Anti-Apoptosis-Enhancing Nuclease antibodyAnti-Interferon-Stimulated 20 Kda Exonuclease-Like 1 antibodyAnti-AEN antibodyAnti-ISG20L1 antibodyAnti-SBBI58 antibody |
Information sourced from Uniprot.org