| Short Description : | Rabbit polyclonal AEBP1 (999-1158) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AEBP1 |
| Gene ID: | 165 |
| Uniprot ID: | AEBP1_HUMAN |
| Immunogen Region: | 999-1158 |
| Immunogen Sequence: | NRPIPHIDPSRPMTPQQRRL QQRRLQHRLRLRAQMRLRRL NATTTLGPHTVPPTLPPAPA TTLSTTIEPWGLIPPTTAGW EESETETYTEVVTEFGTEVE PEFGTKVEPEFETQLEPEFE TQLEPEFEEEEEEEKEEEIA TGQAFPFTTVETYTVNFGDF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 999-1158 of human AEBP1 (NP_001120.3). |
| Tissue Specificity | Expressed in osteoblast and visceral fat. |
| Post Translational Modifications | Phosphorylated by MAPK1 in vitro. |
| Function | Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. |
| Protein Name | Adipocyte Enhancer-Binding Protein 1Ae-Binding Protein 1Aortic Carboxypeptidase-Like Protein |
| Database Links | |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: CytoplasmNucleus |
| Alternative Antibody Names | Anti-Adipocyte Enhancer-Binding Protein 1 antibodyAnti-Ae-Binding Protein 1 antibodyAnti-Aortic Carboxypeptidase-Like Protein antibodyAnti-AEBP1 antibodyAnti-ACLP antibody |
Information sourced from Uniprot.org
