Host: | Goat |
Applications: | Pep-ELISA/WB |
Reactivity: | Human/Dog/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-ADRB2R/ADRB2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000. WB: Approx 48kDa band observed in lysates of cell lind HepG2 (calculated MW of 46.6kDa according to NP_000015.1). Recommended concentration: 0.3-1µg/ml. Primary incubation 1 hour at room t |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | ADRB2 |
Gene ID: | 154 |
Uniprot ID: | ADRB2_HUMAN |
Immunogen Region: | C-Term |
Accession Number: | NP_000015.1 |
Immunogen Sequence: | HQGTVPSDNIDSQ |
Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. |
Protein Name | Beta-2 Adrenergic Receptor Beta-2 Adrenoreceptor Beta-2 Adrenoceptor |
Database Links | Reactome: R-HSA-390696 Reactome: R-HSA-418555 Reactome: R-HSA-5689880 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Early Endosome Golgi Apparatus Colocalizes With Vhl At The Cell Membrane Activated Receptors Are Internalized Into Endosomes Prior To Their Degradation In Lysosomes Activated Receptors Are Also Detected Within The Golgi Apparatus |
Alternative Antibody Names | Anti-Beta-2 Adrenergic Receptor antibody Anti-Beta-2 Adrenoreceptor antibody Anti-Beta-2 Adrenoceptor antibody Anti-ADRB2 antibody Anti-ADRB2R antibody Anti-B2AR antibody |
Information sourced from Uniprot.org