| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ADRB2R/ADRB2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 48kDa band observed in lysates of cell lind HepG2 (calculated MW of 46.6kDa according to NP_000015.1). Recommended concentration: 0.3-1µg/ml. Primary incubation 1 hour at room t |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ADRB2 |
| Gene ID: | 154 |
| Uniprot ID: | ADRB2_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_000015.1 |
| Immunogen Sequence: | HQGTVPSDNIDSQ |
| Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. |
| Protein Name | Beta-2 Adrenergic ReceptorBeta-2 AdrenoreceptorBeta-2 Adrenoceptor |
| Database Links | Reactome: R-HSA-390696Reactome: R-HSA-418555Reactome: R-HSA-5689880Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly EndosomeGolgi ApparatusColocalizes With Vhl At The Cell MembraneActivated Receptors Are Internalized Into Endosomes Prior To Their Degradation In LysosomesActivated Receptors Are Also Detected Within The Golgi Apparatus |
| Alternative Antibody Names | Anti-Beta-2 Adrenergic Receptor antibodyAnti-Beta-2 Adrenoreceptor antibodyAnti-Beta-2 Adrenoceptor antibodyAnti-ADRB2 antibodyAnti-ADRB2R antibodyAnti-B2AR antibody |
Information sourced from Uniprot.org
