| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADRB1 |
| Gene ID: | 153 |
| Uniprot ID: | ADRB1_HUMAN |
| Immunogen Region: | 150-250 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ADRB1 (NP_000675.1). |
| Immunogen Sequence: | CVIALDRYLAITSPFRYQSL LTRARARGLVCTVWAISALV SFLPILMHWWRAESDEARRC YNDPKCCDFVTNRAYAIASS VVSFYVPLCIMAFVYLRVFR E |
| Post Translational Modifications | Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. |
| Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors. |
| Protein Name | Beta-1 Adrenergic Receptor Beta-1 Adrenoreceptor Beta-1 Adrenoceptor |
| Database Links | Reactome: R-HSA-390696 Reactome: R-HSA-418555 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Early Endosome Colocalizes With Rapgef2 At The Plasma Membrane Localized At The Plasma Membrane Found In The Golgi Upon Gopc Overexpression |
| Alternative Antibody Names | Anti-Beta-1 Adrenergic Receptor antibody Anti-Beta-1 Adrenoreceptor antibody Anti-Beta-1 Adrenoceptor antibody Anti-ADRB1 antibody Anti-ADRB1R antibody Anti-B1AR antibody |
Information sourced from Uniprot.org