| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADM |
| Gene ID: |
133 |
| Uniprot ID: |
ADML_HUMAN |
| Immunogen Region: |
50-150 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADM (NP_001115.1). |
| Immunogen Sequence: |
SSYPTGLADVKAGPAQTLIR PQDMKGASRSPEDSSPDAAR IRVKRYRQSMNNFQGLRSFG CRFGTCTVQKLAHQIYQFTD KDKDNVAPRSKISPQGYGRR R |
| Tissue Specificity | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. |
| Function | Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Adrenomedullin: ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex. |
| Protein Name | Pro-Adrenomedullin Cleaved Into - AdrenomedullinAm - Proadrenomedullin N-20 Terminal PeptideProam N-Terminal 20 PeptidePampProam-N20 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Adrenomedullin Cleaved Into - Adrenomedullin antibodyAnti-Am - Proadrenomedullin N-20 Terminal Peptide antibodyAnti-Proam N-Terminal 20 Peptide antibodyAnti-Pamp antibodyAnti-Proam-N20 antibodyAnti-ADM antibodyAnti-AM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
