Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-ADIPOR1 (276-375) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ADIPOR1 |
Gene ID: | 51094 |
Uniprot ID: | PAQR1_HUMAN |
Immunogen Region: | 276-375 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 276-375 of human ADIPOR1 (NP_057083.2). |
Immunogen Sequence: | LSGVVPTMHFTIAEGFVKAT TVGQMGWFFLMAVMYITGAG LYAARIPERFFPGKFDIWFQ SHQIFHVLVVAAAFVHFYGV SNLQEFRYGLEGGCTDDTLL |
Tissue Specificity | Widely expressed. Highly expressed in heart and skeletal muscle. Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. |
Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. |
Protein Name | Adiponectin Receptor Protein 1 Progestin And Adipoq Receptor Family Member 1 Progestin And Adipoq Receptor Family Member I |
Database Links | Reactome: R-HSA-163680 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Localized To The Cell Membrane And Intracellular Organelles |
Alternative Antibody Names | Anti-Adiponectin Receptor Protein 1 antibody Anti-Progestin And Adipoq Receptor Family Member 1 antibody Anti-Progestin And Adipoq Receptor Family Member I antibody Anti-ADIPOR1 antibody Anti-PAQR1 antibody Anti-TESBP1A antibody Anti-CGI-45 antibody |
Information sourced from Uniprot.org