| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Acireductone dioxygenase-requiring-requiring (71-120 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADI1 |
| Gene ID: |
55256 |
| Uniprot ID: |
MTND_HUMAN |
| Immunogen Region: |
71-120 aa |
| Specificity: |
The antibody detects endogenous ADI1 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human ADI1 at the amino acid range 71-120 |
| Function | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. |
| Protein Name | Acireductone DioxygenaseAcireductone DioxygenaseFe(2+-RequiringArd'Fe-ArdAcireductone DioxygenaseNi(2+-RequiringArdNi-ArdMembrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1Mtcbp-1Submergence-Induced Protein-Like FactorSip-L |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinCytoplasmic SideLocalizes To The Plasma Membrane When Complexed To Mmp14 |
| Alternative Antibody Names | Anti-Acireductone Dioxygenase antibodyAnti-Acireductone Dioxygenase antibodyAnti-Fe(2+-Requiring antibodyAnti-Ard' antibodyAnti-Fe-Ard antibodyAnti-Acireductone Dioxygenase antibodyAnti-Ni(2+-Requiring antibodyAnti-Ard antibodyAnti-Ni-Ard antibodyAnti-Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 antibodyAnti-Mtcbp-1 antibodyAnti-Submergence-Induced Protein-Like Factor antibodyAnti-Sip-L antibodyAnti-ADI1 antibodyAnti-MTCBP1 antibodyAnti-HMFT1638 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
