| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Hydroxyacid-oxoacid transhydrogenase, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADHFE1 |
| Gene ID: | 137872 |
| Uniprot ID: | HOT_HUMAN |
| Specificity: | This antibody detects endogenous levels of ADHFE1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human ADHFE1 |
| Function | Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. |
| Protein Name | Hydroxyacid-Oxoacid Transhydrogenase - MitochondrialHotAlcohol Dehydrogenase Iron-Containing Protein 1Adhfe1Fe-Containing Alcohol Dehydrogenase |
| Database Links | Reactome: R-HSA-880009 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Hydroxyacid-Oxoacid Transhydrogenase - Mitochondrial antibodyAnti-Hot antibodyAnti-Alcohol Dehydrogenase Iron-Containing Protein 1 antibodyAnti-Adhfe1 antibodyAnti-Fe-Containing Alcohol Dehydrogenase antibodyAnti-ADHFE1 antibodyAnti-HMFT2263 antibody |
Information sourced from Uniprot.org