| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:10000-1:40000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
ADH5 |
| Gene ID: |
128 |
| Uniprot ID: |
ADHX_HUMAN |
| Immunogen Region: |
1-374 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-374 of human ADH5/GSNOR (NP_000662.3). |
| Immunogen Sequence: |
MANEVIKCKAAVAWEAGKPL SIEEIEVAPPKAHEVRIKII ATAVCHTDAYTLSGADPEGC FPVILGHEGAGIVESVGEGV TKLKAGDTVIPLYIPQCGEC KFCLNPKTNLCQKIRVTQGK GLMPDGTSRFTCKGKTILHY MGTSTFSEYTVVADISVAKI DPLAPLDKVCLLGCGISTGY GAAVNTAKLEPGSVCAVFGL GGVGLAVIMGCKVAGASRII GVDINKDKFARAKEFGATE |
| Function | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation. |
| Protein Name | Alcohol Dehydrogenase Class-3Alcohol Dehydrogenase 5Alcohol Dehydrogenase Class Chi ChainAlcohol Dehydrogenase Class-IiiGlutathione-Dependent Formaldehyde DehydrogenaseFaldhFdhGsh-FdhS-(Hydroxymethylglutathione Dehydrogenase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Alcohol Dehydrogenase Class-3 antibodyAnti-Alcohol Dehydrogenase 5 antibodyAnti-Alcohol Dehydrogenase Class Chi Chain antibodyAnti-Alcohol Dehydrogenase Class-Iii antibodyAnti-Glutathione-Dependent Formaldehyde Dehydrogenase antibodyAnti-Faldh antibodyAnti-Fdh antibodyAnti-Gsh-Fdh antibodyAnti-S-(Hydroxymethylglutathione Dehydrogenase antibodyAnti-ADH5 antibodyAnti-ADHX antibodyAnti-FDH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
