| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADCY1 |
| Gene ID: | 107 |
| Uniprot ID: | ADCY1_HUMAN |
| Immunogen Region: | 470-610 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-610 of human ADCY1 (NP_066939.1). |
| Immunogen Sequence: | NIETFFIVPSHRRKIFPGLI LSDIKPAKRMKFKTVCYLLV QLMHCRKMFKAEIPFSNVMT CEDDDKRRALRTASEKLRNR SSFSTNVVYTTPGTRVNRYI SRLLEARQTELEMADLNFFT LKYKHVEREQKYHQLQDEYF T |
| Tissue Specificity | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Brain, retina and adrenal medulla. |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina. |
| Protein Name | Adenylate Cyclase Type 1Atp Pyrophosphate-Lyase 1Adenylate Cyclase Type IAdenylyl Cyclase 1Ca(2+/Calmodulin-Activated Adenylyl Cyclase |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmMembrane RaftExpressed In The Cytoplasm Of Supporting Cells And Hair Cells Of The Cochlea VestibuleAs Well As To The Cochlear Hair Cell Nuclei And Stereocilia |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 1 antibodyAnti-Atp Pyrophosphate-Lyase 1 antibodyAnti-Adenylate Cyclase Type I antibodyAnti-Adenylyl Cyclase 1 antibodyAnti-Ca(2+/Calmodulin-Activated Adenylyl Cyclase antibodyAnti-ADCY1 antibody |
Information sourced from Uniprot.org
