| Tissue Specificity | Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 22Adam 22Metalloproteinase-Disintegrin Adam22-3Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 2 |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 22 antibodyAnti-Adam 22 antibodyAnti-Metalloproteinase-Disintegrin Adam22-3 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 2 antibodyAnti-ADAM22 antibodyAnti-MDC2 antibody |
Information sourced from Uniprot.org
