| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAM19 |
| Gene ID: | 8728 |
| Uniprot ID: | ADA19_HUMAN |
| Immunogen Region: | 203-460 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-460 of human ADAM19 (NP_150377.1). |
| Immunogen Sequence: | REDLNSMKYVELYLVADYLE FQKNRRDQDATKHKLIEIAN YVDKFYRSLNIRIALVGLEV WTHGNMCEVSENPYSTLWSF LSWRRKLLAQKYHDNAQLIT GMSFHGTTIGLAPLMAMCSV YQSGGVNMDHSENAIGVAAT MAHEMGHNFGMTHDSADCCS ASAADGGCIMAAATGHPFPK VFNGCNRRELDRYLQSGGGM CLSNMPDTRMLYGGRRCGNG YLEDGEECDCGEEEECNNP |
| Tissue Specificity | Expressed in many normal organ tissues and several cancer cell lines. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 19Adam 19Meltrin-BetaMetalloprotease And Disintegrin Dendritic Antigen MarkerMaddam |
| Database Links | Reactome: R-HSA-8941237Reactome: R-HSA-9762292 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 19 antibodyAnti-Adam 19 antibodyAnti-Meltrin-Beta antibodyAnti-Metalloprotease And Disintegrin Dendritic Antigen Marker antibodyAnti-Maddam antibodyAnti-ADAM19 antibodyAnti-MLTNB antibodyAnti-FKSG34 antibody |
Information sourced from Uniprot.org