| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAM19 (203-460) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM19 |
| Gene ID: |
8728 |
| Uniprot ID: |
ADA19_HUMAN |
| Immunogen Region: |
203-460 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 203-460 of human ADAM19 (NP_150377.1). |
| Immunogen Sequence: |
REDLNSMKYVELYLVADYLE FQKNRRDQDATKHKLIEIAN YVDKFYRSLNIRIALVGLEV WTHGNMCEVSENPYSTLWSF LSWRRKLLAQKYHDNAQLIT GMSFHGTTIGLAPLMAMCSV YQSGGVNMDHSENAIGVAAT MAHEMGHNFGMTHDSADCCS ASAADGGCIMAAATGHPFPK VFNGCNRRELDRYLQSGGGM CLSNMPDTRMLYGGRRCGNG YLEDGEECDCGEEEECNNP |
| Tissue Specificity | Expressed in many normal organ tissues and several cancer cell lines. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 19Adam 19Meltrin-BetaMetalloprotease And Disintegrin Dendritic Antigen MarkerMaddam |
| Database Links | Reactome: R-HSA-8941237Reactome: R-HSA-9762292 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 19 antibodyAnti-Adam 19 antibodyAnti-Meltrin-Beta antibodyAnti-Metalloprotease And Disintegrin Dendritic Antigen Marker antibodyAnti-Maddam antibodyAnti-ADAM19 antibodyAnti-MLTNB antibodyAnti-FKSG34 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
