Western blot analysis of various lysates using ACVRL1 Rabbit mAb (STJ11102541) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 10s.

Anti-ACVRL1 antibody (404-503) [S1MR] (STJ11102541)

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STJ11102541
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S1MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:1000-1:6000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACVRL1
Gene ID: 94
Uniprot ID: ACVL1_HUMAN
Immunogen Region: 404-503
Specificity: A synthetic peptide corresponding to a sequence within amino acids 404-503 of human ACVRL1 (P37023).
Immunogen Sequence: VLWEIARRTIVNGIVEDYRP PFYDVVPNDPSFEDMKKVVC VDQQTPTIPNRLAADPVLSG LAQMMRECWYPNPSARLTAL RIKKTLQKISNSPEKPKVIQ
Function Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Protein Name Activin Receptor Type-1-Like
Activin Receptor-Like Kinase 1
Alk-1
Serine/Threonine-Protein Kinase Receptor R3
Skr3
Tgf-B Superfamily Receptor Type I
Tsr-I
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Activin Receptor Type-1-Like antibody
Anti-Activin Receptor-Like Kinase 1 antibody
Anti-Alk-1 antibody
Anti-Serine/Threonine-Protein Kinase Receptor R3 antibody
Anti-Skr3 antibody
Anti-Tgf-B Superfamily Receptor Type I antibody
Anti-Tsr-I antibody
Anti-ACVRL1 antibody
Anti-ACVRLK1 antibody
Anti-ALK1 antibody

Information sourced from Uniprot.org

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