Anti-ACVRL1 antibody (404-503) [S1MR] (STJ11102541)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ACVRL1 (404-503) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:6000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACVRL1 |
| Gene ID | 94 |
| Uniprot ID | ACVL1_HUMAN |
| Immunogen Region | 404-503 |
| Immunogen Sequence | VLWEIARRTIVNGIVEDYRP PFYDVVPNDPSFEDMKKVVC VDQQTPTIPNRLAADPVLSG LAQMMRECWYPNPSARLTAL RIKKTLQKISNSPEKPKVIQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 404-503 of human ACVRL1 (P37023). |
Additional Info
| Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
| Protein Name | Activin Receptor Type-1-LikeActivin Receptor-Like Kinase 1Alk-1Serine/Threonine-Protein Kinase Receptor R3Skr3Tgf-B Superfamily Receptor Type ITsr-I |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-1-Like antibodyAnti-Activin Receptor-Like Kinase 1 antibodyAnti-Alk-1 antibodyAnti-Serine/Threonine-Protein Kinase Receptor R3 antibodyAnti-Skr3 antibodyAnti-Tgf-B Superfamily Receptor Type I antibodyAnti-Tsr-I antibodyAnti-ACVRL1 antibodyAnti-ACVRLK1 antibodyAnti-ALK1 antibody |
Information sourced from Uniprot.org