| Background | Among the six actin isoforms described in mammals, two are found in virtually all cells ( Beta-and Gamma-cytoplasmic) , two are detected in smooth muscle cells ( Alpha-and Gamma-smooth muscle) and two are present in striated muscles, one predominantly in skeletal ( Alpha-skeletal) and one in cardiac ( Alpha-cardiac) muscle cells. These actin isoforms differ slightly in their N-terminus, but the sequence of each of these actins is highly conserved in higher vertebRates. Alpha-muscle actin is present in striated as well as smooth muscle cells, and in pathological tissues derived therefrom.HHF35 reacts with both Alpha-muscle and Gamma-smooth muscle actin, and therefore reacts with skeletal muscle, cardiac muscle, vascular and visceral smooth muscle cells, pericytes and myoepithelial cells. It is also reactive in myofibroblasts. It does not react with epithelial, endothelial, neural or normal connective tissue cells when applied under the proper conditions to these tissue sections. |
Information sourced from Uniprot.org
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