| Short Description : | Rabbit polyclonal anti-Acetyl-Hepatocyte nuclear factor 4-alpha and Hepatocyte nuclear factor 4-gamma-Lys127/79 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:10000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HNF4AHNF4G |
| Gene ID: | 31723174 |
| Uniprot ID: | HNF4A_HUMANHNF4G_HUMAN |
| Immunogen: | Synthetic Acetyl peptide from the human protein at the amino acid range 127 (HNF-4 Alpha ) /79 (HNF-4 Gamma ) |
| Specificity: | This antibody detects endogenous levels of HNF-4 Alpha/Gamma at Human:K127/79;Mouse:K127/79;Rat:K127, It doesn t reacte with total protein. |
| Function | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells. |
| Protein Name | Hepatocyte Nuclear Factor 4-AlphaHnf-4-AlphaNuclear Receptor Subfamily 2 Group A Member 1Transcription Factor 14Tcf-14Transcription Factor Hnf-4 |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 4-Alpha antibodyAnti-Hnf-4-Alpha antibodyAnti-Nuclear Receptor Subfamily 2 Group A Member 1 antibodyAnti-Transcription Factor 14 antibodyAnti-Tcf-14 antibodyAnti-Transcription Factor Hnf-4 antibodyAnti-HNF4A antibodyAnti-HNF4 antibodyAnti-NR2A1 antibodyAnti-TCF14 antibody |
Information sourced from Uniprot.org
